Loose or Damaged Connections: If proper audio contact isn't being made, you'll experience audio issues. Be sure all speaker and equipment connections are secure. Wiggle the cables a bit to see if the problem is with a bad wire.
Interference From Other Devices: Keep motorized devices or equipment that gives off large electromagnetic fields away from your audio gear. Watch out for devices like washers, dryers and refrigerators that may not be properly isolated from the circuit you are plugged into.
Poor Grounding: Some 3-pronged outlets don't have the ground connected. Verify the outlet is properly wired.